Noael

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

No Observed Adverse Effect Level

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DefinitionThis section has been translated automatically.

Acronym for "No Observed Adverse Effect Level". In preclinical pharmaceutical research, NOAEL is an important toxicological endpoint in the determination of toxicity.

Note(s)This section has been translated automatically.

The NOAEL defines in a given study approach the highest dose or exposure concentration of a substance at which no significantly increased adverse treatment-related findings in morphology, function, growth, development or lifespan are observed.
The NOAEL value for a substance always refers to a specific biological measurement procedure with a specific form of application and a specific animal species (often oral application in rodents) or to a defined cell culture system.

If the NOAEL cannot be determined from toxicity studies, the lowest concentration/dose tested at which adverse effects are still observed (LOAEL) shall be reported.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer