Tyrosinase-related protein

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Tyrosinase-related protein (TYRP) is the obsolete name for two enzymes:

  • TRP-1: 5,6-dihydroxyindole-2-carboxylic acid oxidase
  • TRP-2: L-dopachrome tautomerase

General informationThis section has been translated automatically.

The TRYP-1 gene encodes the enzyme "5,6-dihydroxyindole-2-carboxylic acid oxidase" also DHICA oxidase, which catalyses 5,6-dihydroxyindole-2-carboxylic acid in melanin. Mutations in the TYRP1 gene are responsible for oculocutaneous albinism type 3. Animals immunized with this enzyme show the symptoms of Vogt-Koyanagi-Harada syndrome. One allele of TYPR1 in humans is characteristic for blonde-haired inhabitants of the Solomon Islands. Remarkably, this allele does not occur in Europeans. Apparently, melanocytes of Vitiligo under stress express a tyrosinase-related protein that is recognized by the immune system as foreign.

LiteratureThis section has been translated automatically.

  1. Shield M et al (2016) Vitiligo. dermatologist 67: 173-186

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer