Interleukin-14
Synonym(s)
60K-BCGF; BCGF-H; High molecular weight B-cell growth factor; HMW-BCGF; IL-14; Namalwa B-cell growth factor; Namalwa-BCGF; Namalwa-BCGF.
DefinitionThis section has been translated automatically.
Interleukin 14, also known as alpha-taxilin in recent scientific publications, is a protein encoded by the TXLNA gene on chromosome 1.
Interleukin-14 is a cytokine that affects the growth and proliferation of both normal and neoplastic B-cells (see also the synonym "high molecular weight B-cell growth factor").
The cytokine is produced by activated T and malignant B lymphocytes. The interleukin-14 receptor is only expressed on activated, but not on resting B-lymphocytes.
Interleukin 14 induces the proliferation of different types of B-lymphocytes. Subpopulations of B-lymphocytes and inhibits the release of immunoglobulins.
LiteratureThis section has been translated automatically.
- Ambrus JL Jr et al (1991) Induction of proliferation by high molecular weight B cell growth factor or low molecular weight B cell growth factor is associated with increases in intracellular calcium in different subpopulations of human B lymphocytes. Cell Immunol 134:314-324.
- Ford R et al (1995) Identification of B-cell growth factors (interleukin-14; high molecular weight B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas.Blood 86:283-293.
- Mashidori T et al (2011) Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer. Biomed Res 32:103-110.
- Nogami S et al (2004) "Identification and characterization of taxilin isoforms". Biochem. Biophysics. Res. Commun 319: 936-943.