Immunoreceptor tyrosine-based activation motifs

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 18.08.2021

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Synonym(s)

ITAM

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DefinitionThis section has been translated automatically.

Immunoreceptor tyrosine-based activation motifs", ITAMs for short, are highly conserved peptide segments in the cytosolic portion of CD3. ITAMs are important components of the receptor complex belonging to CD3/TCR.

ITAMs are associated with tyrosine kinases and play an important role in signal transduction via the T cell receptor by phosphorylation.

Furthermore, ITAMs are important for B cell development and the activation of B cell receptors and Fc receptors.

Authors

Last updated on: 18.08.2021

Author: Prof. Dr. med. Peter Altmeyer