Di-2-ethylhexylphthalate
Synonym(s)
DefinitionThis section has been translated automatically.
Diethylhexyl phthalate is one of the most important phthalate-based plasticizers. It is the diester of phthalic acid and 2-ethylhexanol. Di-2-ethylhexyl phthalate is also a diluent for epoxy resins. Di-2-ethylhexyl phthalate is also found in cooling lubricants and cosmetic products. Diethylhexyl phthalate was formerly used as a film former and solvent.
Undesirable effectsThis section has been translated automatically.
Larger studies have shown a correlation between atmospheric phthalate exposure and allergic asthma. Furthermore, atopic eczema can be exacerbated. Contact sensitisations are described less frequently.
Note(s)This section has been translated automatically.
When DEHP is incorporated into polymeric materials, they become more elastic and supple. Important: DEHP does not form a chemical compound. It can therefore escape again and diffuse into the food, e.g. from food packaging, or be absorbed perorally from children's toys. DEHP is prohibited in toys and childcare articles.
LiteratureThis section has been translated automatically.
- Bornehag CG et al (2010) Phthalate exposure and asthma in children. Int J Androl 33: 333-345
Carballada Fet al. (2014) Distearyl phthalic acid amide, a new contact allergen. Contact Dermatitis 71:310-312
He M et al (2013) Effects of airway exposure to di-(2-ethylhexyl) phthalates on allergic rhinitis. Immunopharmacol Immunotoxicol 35: 390-395
- Hoppin JA et al (2013) Phthalate exposure and allergy in the U.S. population: results from NHANES 2005-2006 Environ Health Perspect 121:1129-1134
- Lee J et al (2011) Allergy-related cytokines (IL-4 and TNF-α) are induced by di(2-ethylhexyl) phthalates and attenuated by plant-originated glycoprotein (75 kDa) in HMC-1 cells. Environ Toxicol 26: 364-372
- Sadakane K et al (2014) Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice. Immunopharmacol Immunotoxicol 36: 61-69