Central supramolecular activation cluster

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

cSMAC

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DefinitionThis section has been translated automatically.

During activation of T cells by antigen-presenting cells (APZ), a complex structure is formed at the contact zone. Analogous to neuronal synapses, this structure has been termed a mature "immunological synapse" (IS). It consists of an inner activation area, cSMAC (central supramolecular activation cluster). In cSMAC the T-cell receptor, the accessory receptor CD28 and a protein kinase accumulate.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer