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Aldosterone

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

Aldocorten; CAS No: 52-39-1; Electrocorticoid

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DefinitionThis section has been translated automatically.

Most important mineralocorticoid produced in the adrenal cortex. Aldosterone has a half-life of 0.5 hours.

Pharmacodynamics (Effect)This section has been translated automatically.

Responsible for sodium retention and potassium excretion. The hormone has no anti-inflammatory effect. Can be competitively inhibited by spironolactone.

Standard concentrationThis section has been translated automatically.

morning lying: 11,7-239ng/l

after 30min standing: 22,1-353ng/l

Note(s)This section has been translated automatically.

Aldosterone increased(Renin increased):

  • primary adrenocortical insufficiency
  • congenital defects of steroid synthesis (adrenogenital syndrome).

Aldosterone decreased (Renin decreased):

  • Pseudohyperaldosteronism
  • Medication (beta blockers, reserpine, methydopa, clonidine, etc.)

Aldosterone increased (Renin decreased):

  • Primary hyperaldosteronism (e.g. adrenal cortex adenoma)

Aldosterone increased (Renin increased):

  • Renin-forming tumors
  • Pheochromocytoma
  • Hyperthyroidism
  • Edema
  • Medication (calcium antagonists, spironolactone, ACE inhibitors, laxatives)

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer