Myricetin

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Synonym(s)

3,3,4,5,5,7-hexahydroxyflavone

Definition
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Secondary plant substance from the group of flavonoids with strong antioxidant effect (comparable to other flavonoids such as quercetin and rutin). Myricitrin is the 3-rhamnoside of myricetin

Occurrence
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Myricetin usually occurs together with other flavonoids (e.g. Kaempferol, Quercetin, Rutin) in the following plants:

  • black tea
  • blackcurrants
  • Blueberries
  • Myrtle Berries
  • Grapes
  • Walnuts
  • Sundew

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Effects
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In animal experiments, myricetin has an insulin-like effect in addition to its antioxidant properties. It promotes the transport of glucose (sugar) into the cells and stimulates the formation of body fat (lipogenesis). Furthermore, myricetin is said to lower the concentration of LDL cholesterol and to have a positive effect on the development of prostate cancer (however, there are no sufficient clinical test results for this - see below). references below).

Myricetin also inhibits the release of histamine and the formation of the enzyme lipoxygenase. These inhibitory effects may play a role in inflammatory allergic and non-allergic processes. Anticarcinogenic and antimutagenic effects have been demonstrated in animal experiments.

Note(s)
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Versch. Companies advertise preparations containing, besides myricetin, lycopene, phytosterols from saw palmetto fruits, luteolin, pollen extracts, flax lignans as effective remedies against benign prostate hyperplasia. There is a lack of sufficiently robust clinical results.

Literature
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  1. Boam T (2015) Anti-androgenic effects of flavonols in prostate cancer. Ecancermedicalscience 9:585.
  2. Devi KP et al (2015) Molecular mechanisms underlying anticancer effects of myricetin. Life Sci 142:19-25.
  3. Ong KC et al. (1997) Biological effects of myricetin. Gene Pharmacol 29:121 126.

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