Khellin

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Definition
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Khellin, a natural furanochromone (cf. figure) extracted from the fruits of Ammeos visnagae fructus (Khella), is used medicinally mainly for the treatment of vitiligo. Khellin has an obligatory photosensitizing effect.

Khellin also has a spasmolytic effect on the smooth muscles of the bronchi, the gastrointestinal tract and the bile and urinary tracts, and is therefore used in preparations for the treatment of bronchial asthma, angina pectoris, and renal, biliary and intestinal colic (see Ammeos visnagae fructus below).

Indication
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Dosage and method of use
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Take 100 mg about 2 hours before UVA irradiation.

Undesirable effects
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Nausea, orthostatic dysregulation, photosensitization, increase in transaminases, rarely hepatotoxicity.

Recipe(s)
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