Cup primrose

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Synonym(s)

obconian primula; Primrose; Primulaceae

Definition
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Today widely used ornamental plant, originally from China. It was brought to Europe in the 19th century and from there it spread worldwide. Low medicinal use in contrast to other primrose species (e.g. Primula elatior).

Undesirable effects
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Sensitization is triggered by the quinone primin (2-methyl-6-pentyl-1,4-benzoquinone). Sensitizing potency: Very strong. Sensitization frequency: Occasional.

The medically used primrose species (Primula officinalis) contain almost no primin.

Clinical picture
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The literature reports numerous cases of irritant and allergic reactions after contact with the cup primrose. The most common allergic contact eczema today is observed in connection with domestic or hobby gardening activities. Occupational primrose allergies in gardeners or florists are rare. Cross-reactivity can occur in contact with other plants and wood species containing quinones with related structures, such as exotic wood species ( Dalbergia species, rosewood) such as teak or rosewood. Related chinoid constituents are also found in other primrose species, orchid species, etc. as well as marine animals (e.g. in natural sponges).

Note(s)
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Primin appears to have an antineoplastic effect on basal cell carcinoma. Due to its high sensitizing potency it was not used therapeutically. Furthermore, Primin seems to have antibiotic and antimicrobial as well as molluscicidal effects.