DefinitionThis section has been translated automatically.
Pharmacodynamics (Effect)This section has been translated automatically.
Sunitinib (like sorafenib) is a targeted tumor therapy and blocks the tyrosine kinase of the receptors PDGFR (platelet-derived-growth-fctor). Furthermore, sunitinib inhibits the tyrosine kinase of VEGFR (vascular endothelial growth factor - see below VEGF) and c-Kit. It also inhibits some serine threonine kinases (multi-kinase inhibitors). Sunitinib thus switches off the signalling effect of growth factors at the molecular level, which the tumour needs for its growth.
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IndicationThis section has been translated automatically.
Undesirable effectsThis section has been translated automatically.
The major serious side effects of sunitinib are pulmonary embolism (1% of cases), thrombocytopenia (1%), neutropenia with fever (0.4%), and hypertension (0.4%). The most commonly reported adverse events were fatigue/exhaustion (the so-called fatigue syndrome), which affects about one-third of patients. Frequently (>20% of cases), diarrhoea, nausea, stomatitis continue to occur.
Typical side effects on the skin organ are observed from the 3rd-4th week of treatment:
- Hand-foot syndrome
- Xerosis of the skin
- diffuse effluvium with alopecia
- subungual haemorrhages (splinter hemorrhages)
- Depigmentation of skin and hair
- periocular edema.
PreparationsThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Wozel G et al (2010) Undesirable dermatological effects in therapeutic inhibition of the VEGF pathway. JDDG 8: 243-249