The FCGR1A gene (FCGR1A stands for: Fc gamma receptor Ia) is a protein-coding gene located on chromosome 1q21.2. An important paralog of this gene is FCRLB.
FCGR1A gene
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The FCGR1A gene codes for a receptor protein that plays an important role in the immune response. This protein is a high-affinity Fc gamma receptor. The gene is one of three related gene family members located on chromosome 1. The FcγR family recognizes the Fc portion of IgG and is divided into several major classes (FcγRI, FcγRII, and FcγRIII) consisting of activating and inhibitory receptors that additionally differ in their affinities for IgG and are specific for the individual IgG subclasses.
Fc receptors are predominantly membrane-bound receptors for different immunoglobulin isotypes. Fc receptors are glycosylated. They are found on the surface of phagocytes, B lymphocytes, NK cells and dendritic cells.
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A strong correlation between serum levels of IL-37 and the expression of FCGR1A (CD64) on activated monocytes and their subsets in the peripheral blood of patients with rheumatoid arthritis has been demonstrated (Mokhtar ER et al. 2025).
FCGR1A is highly expressed in various types of cancer. FCGR1A was significantly correlated with overall survival (OS) in cervical and endocervical carcinoma (CESC), cholangiocarcinoma (CHOL), clear cell renal carcinoma (KIRC) and melanoma of the skin. A high expression of FCGR1A meant a better prognosis. FCGR1A showed significant differences in different stages of KIRC and SKCM. In addition, FCGR1A was significantly associated with the infiltration level of CD4+ T cells, CD8+ T cells, B cells, macrophages, neutrophils and dendritic cells in the four cancer types. This shows that FCGR1A is involved in many pathophysiological processes. It correlates most strongly with FCGR3A. The FCGR3A gene showed highly significant positive correlations with FCGR1A in four cancer types (Xu JL et al. 2020).
LiteratureThis section has been translated automatically.
- Bruhns P (2012) Properties of mouse and human IgG receptors and their contribution to disease models. Blood 119:5640-5649)
- Gessner JE et al (2013) Fcγ receptors [Fcγ receptors]. Z Rheumatol 72:68-70.
- Mokhtar ER et al. (2025) FCGR1A(CD64) expression on monocyte subsets and FIL1Z(IL-37) serum level as biomarkers of rheumatoid arthritis activity: A case controlled study and in silico analysis. Pathol Res Pract 269:155910.
- Schmidt RE et al. (2005) Fc receptors and their interaction with complement in autoimmunity. Immunol Lett 100:56-67).
- Ruyssen-Witrand A et al. (2012) Fc gamma receptor type IIIA polymorphism influences treatment outcomes in patients with rheumatoid arthritis treated with rituximab. Ann Rheum Dis 71:875-877).
- Xu JL et al. (2020) Serves as a Novel Biomarker and Correlates With Immune Infiltration in Four Cancer Types. Front Mol Biosci 7:581615.