The DSG3 gene (DSG3 stands for: Desmoglein 3) is a protein-coding gene located on chromosome 18q12.1. This gene encodes a member of the desmoglein family and the cadherin cell adhesion molecule superfamily of proteins. The DSG3 gene is located in a gene cluster with other members of the desmoglein gene family on chromosome 18. An important paralog of this gene is DSG4.
DSG3 gene
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Desmogleins are calcium-binding transmembrane glycoprotein components from the cadherin group that occur in cell-cell junctions between epithelial, myocardial and other cell types. In the skin, desmoglein 1 and desmoglein 3 are predominantly expressed in intercellular junctions. They function as adhesion molecules in desmosomes. In adults, desmoglein 1 is expressed in all skin layers, desmoglein 3 predominantly in the stratum basale and stratum granulosum. The encoded preproprotein is proteolytically processed to form the mature glycoprotein.
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- Koch PJ et al. (1998) Desmoglein 3 anchors telogen hair in the follicle. J Cell Sci 111 ( Pt 17):2529-2537.
- Rötzer V et al. (2016) Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing. J Invest Dermatol 136:301-310.
- Tsang SM et al. (2012) Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol 227:81-93.
- Uttagomol J et al. (2019) Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces. Int J Mol Sci 20:6221.