DefinitionThis section has been translated automatically.
Busulfan is a bifunctional alkylan, a sulfonic acid alkyl ester, which alkylates nucleic acids and proteins in the cell by splitting off the methanesulfone groups. Busulfan can be applied orally as well as intravenously.
IndicationThis section has been translated automatically.
Busulfan is orally approved for the palliative treatment of chronic myeloid leukemia (CL). This therapy is largely abandoned today, as the tyrosine kinase inhibitor Imatinib provides a much better therapeutic principle.
The preferred field of application of Busulfan today is the conditioning treatment prior to stem cell transplantation. For this purpose the drug is typically used in combination with cyclophosphamide.
Undesirable effectsThis section has been translated automatically.
Liver dysfunction: hyperbilirubinemia, icterus, hepatic vein occlusion, fibrosis with hepatocellular necrosis
Interstitial pneumonia (J84.9)
Pulmonary fibrosis (busulfan lung - Pearl M 1977) (J84.9)
Pericardial fibrosis (Terpstra W et al 1989)(I31.9)
Cataract formation (Honda A et al 1993)
Hyperpigmentation of the skin (Simonart T et al. 1999)
Enhancement of local radiotherapeutic effects -s.a. under Radiation Recall (Vassal G et al. 1989)
LiteratureThis section has been translated automatically.
- Dahlgren S et al (1972) Clinical and morphological side-effects of busulfan (Myleran) treatment. Acta Med Scand 192:129-135.
- Honda A et al (1993) Nippon Ganka Gakkai Zasshi 97:1242-1245.
- Pearl M (1977) Busulfan lung. On J Dis Child 131:650-652.
- Terpstra W et al (1989) Pericardial fibrosis following busulfan treatment. Neth J Med 35:249-252.
- Simonart T et al (1999) Hyperpigmentation inducite par le busulfan: une observation avec étude ultrastructurale [Hyperpigmentation induced by busulfan: a case with ultrastructure examination]. Ann Dermatol Venereol 126:439-440.
- Vassal G et al (1989) Enhanced cutaneous radiation effects following high-dose busulfan therapy. Cancer chemother Pharmacol 23:117-118.