Thiazines

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Thiazine refers to a heterocyclic organic compound with a ring of 4 carbon, 1 nitrogen and 1 sulphur atom.

Different arrangements of the N atom in relation to the S atom result in different derivatives with different functions.

The most common basic structure in the different thiazine derivatives concerns the 1,4-thiazine. The simplest 1,4-thiazine compound is the 1,4-thiazine (C4H5NS) itself. Other important derivatives are derived from 1,2-thiazine and 1,3-thiazine.

Thiazines can be found as a basic structure in dyes (thiazine dyes), sedatives, antibiotics (cephalosporins) and insecticides. Examples are phenothiazines derived from 1,4-thiazine (e.g. methylene blue) or diuretics such as hydrochlorothiazide.

Important representatives of 1,3-thiazines are cephalosporin antibiotics(e.g. cephaloclor, cephadroxil, cephalotin, etc.) and the sedative painkiller xylazine, which is widely used in veterinary medicine.

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Cephalosporins; Methylene blue;

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Last updated on: 29.10.2020