Sebaceous epithelioma D23.L2

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

sebaceoma; sebaceous epithelioma; Sebazeoma

Definition
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Controversial term (especially in the Anglo-American language area) for adnexal tumors with differentiation of sebaceous glands, which show only a moderate degree of differentiation. Nosologically they are located between the sebaceous adenoma and the sebaceous carcinoma. Sebaceous epitheliomas often occur in a sebaceous nevus.

Manifestation
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Predominantly occurring after the age of 50. Men are more frequently affected than women.

Localization
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Located mainly on the face and ear region.

Clinical features
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Clinically uncharacteristic 0.5-12.0 cm large, skin-coloured or slightly yellowish lumps. The diagnosis is usually a random histological finding.

Histology
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Well-defined, cell-rich, dermal tumor with barely recognizable differentiation of the sebocytes. Basoid, basophilic seboblastic cells predominate. Mitosis occurs. In the parenchyma there are irregularly distributed, partially cystically dilated duct structures.

Differential diagnosis
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Therapy
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Excision in healthy individuals with a small safety margin.

Literature
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  1. Betti R et al (2001) Sebaceoma arising in association with seborrheic keratosis. At J Dermatopathol 23: 58-561
  2. Horio T et al (2003) Photodynamic therapy of sebaceous hyperplasia with topical 5-aminolaevulinic acid and slide projector. Br J Dermatol 148: 1274-1276
  3. Kaddu S et al (1999) Trichoblastoma and sebaceoma in nevus sebaceus. At J Dermatopathol 21: 552-556
  4. Kruse R et al (2003) Frequency of microsatellite instability in unselected sebaceous gland neoplasias and hyperplasias. J Invest Dermatol 120: 858-864
  5. Luba MC et al (2003) Common benign skin tumors. On Fam Physician 67: 729-738
  6. Misago N et al (2002) Sebaceoma and related neoplasms with sebaceous differentiation: a clinicopathologic study of 30 cases. At J Dermatopathol 24: 294-304
  7. Misago N et al (2001) Sebaceous carcinoma, trichoblastoma, and sebaceoma with features of trichoblastoma in nevus sebaceus. At J Dermatopathol 23: 456-462
  8. Misago N et al (2001) Rippled-pattern sebaceoma. At J Dermatopathol 23: 437-443

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020