DefinitionThis section has been translated automatically.
LocalizationThis section has been translated automatically.
Located mainly on the face, capillitium and neck, less frequently on the upper trunk. Rarely also occurring in the area of the oral mucosa.
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Clinical featuresThis section has been translated automatically.
Mostly solitary, soft, easily distinguishable, skin-coloured or slightly yellowish papules/nodes of 0.5 (maximum) 2.0 cm diameter. The clinical findings are otherwise uncharacteristic. Only the slightly yellowish colour may indicate sebaceous differentiation. In this respect the diagnosis is made histologically.
Notice! Multiple sebaceous gland adenomas in combination with carcinomas of the internal organs are suspected of Muir-Torre syndrome.
HistologyThis section has been translated automatically.
Well defined, lobar adenoma in the upper and middle dermis with recognizable differentiation of sebocytes. In addition to sebocytes there are basaloid, basophilic seboblastic cells. The seboblasts condense at the periphery of the lobules to form a multilayer strip. There is extensive contact with the surface epithelium.
TherapyThis section has been translated automatically.
Excision if cosmetically disturbing.
LiteratureThis section has been translated automatically.
- Abbott JJ et al (2003) Cystic sebaceous neoplasms in Muir-Torre syndrome. Arch Catholic Lab Med 127: 614-617
Boennelycke M et al (2015) Sebaceous neoplasms and the immunoprofileof
mismatch-repair proteins as a screening target for syndromic cases. Catholic ResPract
Marques-da-Costa J (2014) Sebaceous adenoma: clinics, dermatoscopy, and histopathology.
Int J Dermatol doi: 10.1111/ijd.12722
McBride SR et al (2002) Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. J Clin Pathol 55: 763-766
- Misago N et al (2002) Sebaceoma and related neoplasms with sebaceous differentiation: a clinicopathologic study of 30 cases. At J Dermatopathol 24: 294-304
- Popnikolov NK et al (2003) Loss of mismatch repair proteins in sebaceous gland tumors. J Cutan Pathol 30: 178-184
- Zutsu T et al (2003) Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature. Int J Oral Maxillofac Surgery 32: 423-426
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.