DefinitionThis section has been translated automatically.
Virustatic. HIV protease inhibitor.
Half-lifeThis section has been translated automatically.
3 h
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IndicationThis section has been translated automatically.
Combination therapy of HIV infection.
Notice! Complete cross-resistance to Indinavir
.Limited indicationThis section has been translated automatically.
Pregnancy, kids.
Dosage and method of useThis section has been translated automatically.
300 mg/day p.o., with simultaneous administration of indinavir 150 mg/day p.o.
Undesirable effectsThis section has been translated automatically.
Diarrhea, headaches, perioral paresthesias, increases in transaminases and triglycerides.
InteractionsThis section has been translated automatically.
Clarithromycin and erythromycin, fluconazole and ketoconazole increase the level of ritonavir, indinavir even by 170%. The effect of oral contraceptives becomes unreliable. Decrease the activity of many drugs ( analgesics, anticoagulants, glucocorticoids, beta-blockers).
PreparationsThis section has been translated automatically.
Norvir®
LiteratureThis section has been translated automatically.
- Eron JJ JR (2002) HIV-1 protease inhibitors. Clin Infect Dis 30: 160-170
Prof. Dr. med. Peter Altmeyer