Poikiloderma (overview) L81.89

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 17.12.2023

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Synonym(s)

congenital poikiloderma; Congenital poikiloderma; Poikilodermia acquired

Definition
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Poikiloderma (poikilos = mottled, marbled) refers to clinically morphologically defined, etiologically different, congenital or acquired, variegated clinical pictures with circumscribed or diffuse atrophy, small-spotted to reticular hyper- and depigmentation, telangiectasia and erythema. Poikiloderma can occur in genetic, inflammatory and neoplastic diseases.

Poikiloderma is typical in cases of chronic UV exposure of the skin or as X-ray late forlgen (radioderm).

The term "poikiloderma" is also used to describe clinical pictures that can be classified as pre-ageing syndromes.

Classification
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A distinction is made according to origin or association with syndromes:

Congenital (primary) poikiloderma (classification in the narrower sense, poikiloderma as a dermatological-clinical signature is indicative of an underlying polyorganic syndrome).

Poikiloderma in the context of other congenital syndromes:

Symptomatic (secondary) poikiloderma (in the context of chronic skin damage, chronic inflammatory or neoplastic underlying diseases):

Histology
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Due to the various causes, the histology of poikiloderma can be very variable. Common to all forms is an atrophic epidermis with striated rectal ridges, mild hyperkeratosis, pigment incontinence with melanophages in the papillary body and telangiectasia. Occasionally, vacuolization of the junctional zone with lymphocytes and dyskeratosis is detectable.

Literature
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  1. Vogl A et al (2005) Skin and alcohol. J Dtsch Dermatol Ges 3: 788-790

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 17.12.2023