Pidobenzone

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

4-hydroxyphenyl ester; 4-Hydroxyphenyl ester; 5-oxo; CAS No: 138506-45-3; L-Proline; Pidobenzone

Definition
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Pidobenzone, an amino acid ester of hydroquinone, is a topically applied active ingredient used for the treatment of melasma (chloasma).

Note(s)
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The treatment of melasma with 4% pidobenzone is described as safe and effective. Allergic reactions have not been reported so far. However, there are no reliable results regarding the allergological relevance of the preparation. Especially in comparison to hydroquinone the advantages of the preparation are not clearly defined.

Literature
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Campanati A et al (2016) Efficacy and Safety of Topical Pidobenzone 4% as Adjuvant Treatment for Solar Lentigines: Result of a Randomized, Controlled, Clinical Trial. Dermatology 232:478-483.

Zanierei et al (2008): Melasma: successful treatment with pidobenzone 4% (K5lipogel) Dermatol Ther 21: Suppl 1, 18-19.

Outgoing links (2)

Hydroquinone; Melasma;

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Last updated on: 29.10.2020