Pemphigoid group (overview) L12.-

Authors: Prof. Dr. med. Peter Altmeyer, Noemi Glarner

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Last updated on: 08.01.2021

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Synonym(s)

Pemphigoid diseases; Pemphigoid Group; Pemphigoids

Definition
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Group of chronic autoimmune diseases characterized by autoantibodies against hemidesmosal structural proteins (BP230, BP180 and others). Binding of the antibody to the antigen in question results in loss of epithelial adherence. Clinical hallmark of pemmphigoid disease is pruritic, subepidermal, large, turgid blisters. Sometimes association with neurologic disease (e.g., Parkinson's disease).

The most common representative of this group of diseases is bullous pemphigoid.

Classification
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Differentiated according to clinic and target antigen:

Occurrence/Epidemiology
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m>f

Manifestation
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Age of onset usually after the 7th decade.

Direct Immunofluorescence
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Indirect immunofluorescence
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S.u. pemphigoid antibodies. The so-called salt split skin examination facilitates the differential diagnosis of blistering dermatoses.

Differential diagnosis
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Literature
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  1. Feliciani C et al (2015) Management of bullous pemphigoid: the European Dermatology Forum consensus in collaboration with the European Academy of Dermatology and Venereology. Br J Dermatol 172:867-876
  2. Gammon WR et al (1992) Immunofluorescence on split skin for the detection and differentiation of basement membrane zone autoantibodies. J Am Acad Dermatol 27: 79-87

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 08.01.2021