DefinitionThis section has been translated automatically.
Group of chronic autoimmune diseases characterized by autoantibodies against hemidesmosal structural proteins (BP230, BP180 and others). Binding of the antibody to the antigen in question results in loss of epithelial adherence. Clinical hallmark of pemmphigoid disease is pruritic, subepidermal, large, turgid blisters. Sometimes association with neurologic disease (e.g., Parkinson's disease).
The most common representative of this group of diseases is bullous pemphigoid.
ClassificationThis section has been translated automatically.
Differentiated according to clinic and target antigen:
- Bullous pemphigoid (BP 180 = type XVII collagen; BP230; plectin).
- Linear IgA dermatosis (BP 180 = type XVII collagen; LAD-1)
- Anti-p200 pemphigoid (laminin gamma 1)
- Anti-p105 pemphigoid (type IV collagen)
- Anti-plectin pemphigoid (plectin)
- Anti-type IV collagen p emphigoid (type IV collagen)
- Lichen planus pemphigoides (BP180; BP230, 200 KDa protein)
- Pemphigoid gestationis (BP180; BP230)
- Juvenile pemphigoid
- Seborrheic pemphigoid
- Epidermolysis bullosa acquisita
- Scarring p emphigoid (mucous membrane pemphigoid) (type XVII collagen) Special form: Scarring pemphigoid type Brunsting-Perry
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Occurrence/EpidemiologyThis section has been translated automatically.
ManifestationThis section has been translated automatically.
Age of onset usually after the 7th decade.
Direct ImmunofluorescenceThis section has been translated automatically.
Indirect immunofluorescenceThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Feliciani C et al (2015) Management of bullous pemphigoid: the European Dermatology Forum consensus in collaboration with the European Academy of Dermatology and Venereology. Br J Dermatol 172:867-876
- Gammon WR et al (1992) Immunofluorescence on split skin for the detection and differentiation of basement membrane zone autoantibodies. J Am Acad Dermatol 27: 79-87
Incoming links (7)Anti-p105 pemphigoid; Anti-type iv collagen pemphigoid; Eosinophilia skin changes; Immunofluorescence; Keratosis follicularis akneiformis, type siemens; Pemphigoids; Pruritus cum materia;
Outgoing links (17)Anti-p105 pemphigoid; Anti-p200 pemphigoid; Anti-plectin pemphigoid; Anti-type iv collagen pemphigoid; Blistering skin diseases (overview); Epidermolysis bullosa acquisita; Juvenile pemphigoid; Lichen planus pemphigoides; Linear iga dermatosis; Mucous membrane pemphigoid; ... Show all
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.