Mepivacaine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

CAS number: 1722-62-9; CAS number: 96-88-8 (Racemat, freie Base); (±)-N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide; rac-N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide; RS)-N-(2,6-dimethylphenyl)-1-methyl-piperidine-2-carboxamide (IUPAC)

Definition
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Mepivacaine is a local anaesthetic of the amide type (prototype is lidocaine) with the molecular formula: C15H22N2O. Mepivacaine is mainly used for infiltration and conduction anaesthesia.

Pharmacodynamics (Effect)
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Mepivacaine, like all Na+ blockers, leads to a blockade of the voltage-dependent Na channels. The influx of sodium into the nerve fibre is inhibited, the formation of an action potential is prevented.

Mepivacaine hydrochloride is a racemate of the (R)-form and (S)-form. In the field of block anaesthesia it is often used for peripheral nerve blocks. Mepivacaine has a rapid onset of action due to good diffusion in tissue and a duration of action between 1.5 and 3 hours.

Standard concentration
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0,5-4 % (maximum 3 mg/kg bw).

Undesirable effects
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Depending on the plasma level, neurological and cardiac symptoms (e.g. cardiac arrhythmia) may occur (e.g. under local anaesthetics)

Preparations
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Meaverin®, Scandicain®

Incoming links (1)

Local anaesthetics;

Outgoing links (1)

Local anaesthetics;

Authors

Last updated on: 29.10.2020