Synonym(s)
Butterfly lichen; Erythematodes; LE; Leloir's disease; Lupus; lupus erythematosus
HistoryThis section has been translated automatically.
Cazenave, 1850; Leloir 1890
DefinitionThis section has been translated automatically.
Mono- or polytopic, complex autoimmune disease (see also autoantibodies) with a predominantly polygenic disposition characterised by an incorrect elimination of extracellular antigens. This leads to a loss of tolerance and a consecutive pathological immune stimulation with specificity for the body's own antigens.
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ClassificationThis section has been translated automatically.
Main forms:
LaboratoryThis section has been translated automatically.
Occurrence of autoantibodies in various autoimmune diseases Autoimmune diseases
| Disease patterns and common targets of autoantibodies (antigens) | |
| Disease pattern | Autoantibodies or antigens |
| Anti-phospholipid antibody syndrome (APS) | Lupus anticoagulant, cardiolipin, ß2-glycoprotein |
| Graves' disease, M. | TSH receptor |
| Chronic polyarthritis (rheumatoid arthritis) | Rheumatoid factor, ANA, histones, ssDNA, fillaggrin |
| CREST syndrome | Centromere (ACA) |
| Enteritis regionalis (Crohn's disease) | ASC |
| Dermatitis herpetiformis Duhring | Endomysium, gliadin, epidermal tissue transglutaminase |
| Dermatomyositis/Polymyositis | PM-Scl, Jo-1, MI2, ssDNA, Ku |
| Mixed Connective Tissue Disease | n-RNP, ss-DNA |
| Pemphigoid | BPAG 1 (BP 230), BPAG 2 (BP 180), Epiligrin |
| Pemphigus | desmoglein 1, desmoglein 3, plakoglobin, STAG |
| periarteritis nodosa | p-ANCA, MPO |
| Systemic scleroderma or circumstrictive scleroderma | SCL-70, ACA |
| Sjögren's syndrome | SS-A, SS-B, rheumatoid factor, salivary gland excretory ducts |
| Systemic lupus erythematosus (SLE) | ds-DNA, ssDNA, Sm antigen, SS-A, SS-B |
| Drug-induced SLE | ss-DNA, Histones |
| Wegener's granulomatosis | c-ANCA, PR3 |
| Sprue, Celiac disease | endomysium, gliadin, tissue transglutaminase |
LiteratureThis section has been translated automatically.
- Cazenave PL (1850) Des principales formes du lupus et de son traitement. Gazette of the hôpitaux (Paris) 3 sér. 2: 393
- Cazenave PL (1850) Des principales formes du lupus et de son traitement. Gazette of the hôpitaux (Paris) 3 sér. 4: 114
- Günther C (2015) Genetics of lupus erythematosus. dermatologist 66: 121-130
- Leloir HC (1890) Recherches sur l'histologie pathologique et al nature du lupus érythémateux. Annales de dermatologie et de syphilographie (Paris) 1: 708-709
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Acrokeratosis paraneoplastic; Angiolupoid; Autoimmune diseases; Biopsy; Bloom syndrome; Butterfly lichen; Cheilitis simplex; Chilblain lupus; Chloroquine; Collagen, injectable; ... Show allOutgoing links (4)
Autoantibodies; Autoimmune diseases; Cutaneous lupus erythematosus (overview); Lupus erythematosus systemic;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
