Leukemias, lymphatic of the skin C91.7

Single, localized or disseminated, specific, macular, papular or nodular skin infiltrates in the different forms of lymphocytic leukemias.

Primarily seen in patients with B-cell type chronic lymphocytic leukemia (B-CLL).

Less frequently, specific skin infiltrates are seen in:

• acute lymphoblastic leukemia/lymphoma
• T-cell large lymphocytic leukemia
• prolymphocytic leukemia
• T-cell leukemia with large granular lymphocytes and
• hairy cell leukemia.

In most cases, specific skin infiltrates are found in the presence of pre-existing, hematologically oncologically proven underlying disease. Rarely they precede the manifest lymphatic systemic disease.

S.a. Leukaemias myeloid of the skin

1. Parsi M et al (2021) Leukemia Cutis. 2021 Jul 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing PMID: 31082180.
2. Robak E et al. (2021) Skin changes in hairy cell leukemia. Ann Hematol100: 615-625.
3. Yang M et al. (2020) Chimeric antigen receptor-modified T-cell therapy for bone marrow and skin relapse Philadelphia chromosome-like acute lymphoblastic leukemia: A case report. Medicine (Baltimore) 99:e18639.
4. Yagi H et al. (2003) Cutaneous type of adult T cell leukemia/lymphoma: a new entity among cutaneous lymphomas. J Dermatol 30: 641-643