Leukaemias myeloic of the skin C92.7

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

AML

Definition
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Specific skin lesions in various subtypes of acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), chronic myelomonocytic leukaemia (CMML) S.a. leukemias of the skin.

Occurrence/Epidemiology
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Specific skin infiltrates may occur within the framework of the already diagnosed underlying disease (usually during a blast episode) or precede it by weeks or months.

Clinical features
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  • Integument: 0.5-5.0 cm tall, usually sharply defined, firm, blue to brown-red, sometimes blue-grey to livid red, slightly necrotic papules, plaques or nodules. Confluence of small foci results in plate-like, flat, pale, blue-grey to bluish-red, smooth or bumpy, solid plaques which may become haemorrhagic due to the frequently accompanying thrombocytopenia.
  • Mucous membranes (especially of the oral cavity and pharynx): haemorrhages, reddish to violet, nodular or plate-like infiltrates which are moderately coarse and sometimes overgrow the teeth.
  • Only very rarely are tumours which acquire a greenish colour through intramural production of porphyrins and are therefore called chloroma.

Histology
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In all layers of the corium, often also in the subcutaneous tissue, cell dense, partly diffuse, partly nodular infiltrates of immature cells of the myeloid series (myelocytes, metamyelocytes, eosinophil metamyelocytes, segmented neutrophil granulocytes); in addition lymphocytes, mast cells and phagocytizing histiocytes. In myelosarcoma, medium to large pleomorphic cells of the granulocyte series and blasts predominate. Immunohistologically, strong positivity results when stained with myeloperoxidase (MOP), lysozyme and MT1 (CD 43).

Therapy
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Treatment of the underlying disease by oncologists.

Literature
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  1. Kaddu S et al (1999) Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 40: 966-978
  2. Lane JE et al (2002) Cutaneous sclerosing extramedullary hematopoietic tumor in chronic myelogenous leukemia. J Cutan catheter 29: 608-612
  3. Mangla A et al (2015) Aleukaemic leukaemia cutis. Br J Haematol 170:4
  4. Pulido-Díaz N et al. (2015) Cutaneous manifestations of leukemia. Rev Med Inst Mex Seguro Soc 53 Suppl 1: 30-35

Outgoing links (1)

Leukemias of the skin;

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020