Isoniazid

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

INAH; INH; Isoniazidium; Isonicotinic acid hydrazide

Definition
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Half-life
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2.2-7.5 h (slow acetylators), 0.6-2 h (fast acetylators) S.a. under N-acetyltransferases

Indication
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Agent of choice in tuberculosis, only in combination therapies (rapid development of resistance in monotherapy).

Limited indication
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Disorders of hematopoiesis.

Dosage and method of use
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5 mg/kg bw/day p.o. or i.v. for at least 6 months. Children: 10-15 mg/kg bw.

Remember! During pregnancy a combination with ethambutol and rifampicin is possible!

Undesirable effects
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Fever, BB changes, gynecomastia, gastrointestinal disorders, liver damage, allergic reactions, drug-induced lupus erythematosus, headaches, dizziness, paresthesias, arthralgias.

Interactions
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s. Table 1.

Contraindication
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Psychoses, epilepsy, liver and kidney diseases.

Preparations
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Isozide, Tebesium

Tables
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Significant interactions of isoniazid

Alcohol

Alcohol Tolerance ↓

Antiepileptic drugs

Effect of the antiepileptic drugs ↑

β blocker

Isoniazid mining ↓

Carbamazepine

Carbamazepine levels ↑

Insulin

Isoniazid levels ↑

Phenytoin

Phenytoin effect ↑

protionamide

Protionamide levels ↑

Authors

Last updated on: 29.10.2020