Incident light microscopy, pigment network breaks at the edges of tumours

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

abrupt break of the pigment pattern; abrupt cut-off of the pigment pattern; abrupt loss of pigment in the trabeculae; Abrupt pigment breaks in the trabecula

Definition
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Reflected light microscopic feature in which the pigmentation of the net trabeculae does not gradually decrease peripherally and changes into the normal skin colour, but breaks off abruptly. The peripheral area is affected as a whole or in sections.

General information
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  • Reflected light microscopy: Reteleiste, which project themselves into the reflected light plane as a net trabecula, appear interrupted or abruptly ending, not only in the tumor margins, but often also centrole lesionally.
  • The specificity for malignant melanomas and dysplastic nevi is 80%, the sensitivity is 40%. Benign nevi show less frequently abrupt pigment network breaks (about 30%).

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Last updated on: 29.10.2020