HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Descriptive term for a series of rare, heterogeneous, predominantly benign tumors that are characterized by the predominant occurrence of granular cells. In the skin and in the mucous membranes close to the skin, most granular cell tumours are of neurogenic origin and also show a close relationship morphologically to peripheral nerves. Clinically, the tumors are uncharacteristic. Thus, the diagnosis is usually an incidental finding.
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ManifestationThis section has been translated automatically.
LocalizationThis section has been translated automatically.
Occurrence is possible on the whole integer. The tongue, lips, thorax and extremities are frequently affected (Tobouti PL et al. 2017). Infection of internal organs is possible.
Clinical featuresThis section has been translated automatically.
HistologyThis section has been translated automatically.
- Mostly a compact tumour penetrating the entire dermis with nests and strands of oval to polygonal, distended cells with eosinophil granulated cytoplasm. The cell nuclei are usually small and pynotic and are located in a decentralized position. A characteristic feature of granular cell tumors is a clearly acanthotic, orthokeratotic surface epithelium covering the tumor parenchyma.
- Immunohistochemistry: Tumor cells are positive for S100, neuron-specific enolase and myelin basic protein, among others.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
Progression/forecastThis section has been translated automatically.
Favourable, very rarely malignant degeneration (1-2%). In case of multiple infestation clinical control examinations.
Note(s)This section has been translated automatically.
Originally, Abrikossoff described the granular cell tumors as myogenic tumors. It was not until 23 years later that the Austrian pathologist Feyrter was able to prove their neurogenic genesis. Today, the tumors are considered to be a variant of schwannoma.
LiteratureThis section has been translated automatically.
Abrikossoff AP (1926) Ueber Myome, ausgehend von der quergestreiften willkuerlichen Muskulatur. Virchows Arch 260: 215-233
Bergner T et al (1991) Solitary and multiple granular cell tumors. Dermatologist 42: 162-167
- Bulstrode NW et al (2004) Granular cell tumour of the glans penis. Br J Plast Surg 57: 83-85
- Feyrter F (1949) On the granular neurogenic growths. Beitr Pathol Anat 110: 181-209
- Gross VL (2002) Multiple cutaneous granular cell tumors: a case report and review of the literature. Cutis 69: 343-346
- Packeisen J et al (2002) Epulis in a newborn. histogenetic comparison with a granular cell tumor in adults. Pathologist 23: 145-148
- Schmidt O et al. (2003) Recurrence and rapid metastasis formation of a granular cell tumor of the vulva. Eur J Obstet Gynecol Reprod Biol 106: 219-221
- Stefansson K et al (1982) S-100 protein in granular cell tumors. Cancer 49: 1834-1838
- Tobouti PL et al. (2017) Extra-tongue oral granular cell tumor: Histological and immunohistochemical
- aspect. Med Oral Patol Oral Cir Bucal 22:e31-e35.
Incoming links (10)Abrikossoff tumor; Cd68; Dermatofibroma; Foam cell tumor; Granular cell myoblastoma; Hibernoma; Myeloblastic myoma; Myoblastic myoma; Neural tumors; Neurom, granular;
Outgoing links (8)Dermatofibroma; Excision; Fibroma; Keloid (overview); Leukoplakia; S100 proteins; Schwannom; Xanthome;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.