Synonym(s)
HistoryThis section has been translated automatically.
Meigs and Pepper, 1870; Zahorsky, 1910
DefinitionThis section has been translated automatically.
Sporadically occurring, aerosol-spreading, characteristically lasting for 3 days ("three-day fever"), highly febrile, virus-induced "childhood disease" (HHV-6 (occasionally also HHV-7), a DNA virus from the herpes family) with permanent immunity.
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PathogenThis section has been translated automatically.
Human DNA virus from the herpes family (HHV-6 and 25% by HHV-7). S.u. Herpes viruses, human.
ManifestationThis section has been translated automatically.
Occurs in 95% of cases in the 6th month to 3 years before age; rarely in adulthood.
Clinical featuresThis section has been translated automatically.
Incubation period: 3-7 days. Onset with lassitude, fatigue, possibly mild or moderate sore throat; sudden (subitum) rise in fever to 39-40 °C, critical fall after 3 days.
Volatile pinkish exanthema, progressing centrifugally from the trunk to the extremities, usually excluding the face, rubeoliform or morbilloid. Lymphadenopathy
Occasional papular enanthem around the uvula and soft palate (so-called "Nagayama spots").
In adults, analogous exanthema with lymphadenopathy.
In adults, the primary infection is accompanied by a highly febrile clinical picture with maculo-papular exanthema, gastroenteritis, lymphadenopathy, and possible complicating hepatitis and meningoencephalitis.
LaboratoryThis section has been translated automatically.
HistologyThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
Complication(s)This section has been translated automatically.
External therapyThis section has been translated automatically.
Internal therapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Fried I et al (2009) HHV-6 infection - not always a three-day fever. SDDG 7: 234-236
- Meigs JF, Pepper W (1870) A practical treatise of the diseases of children. Lindsay and Blakiston, Philadelphia, pp. 701-703 and 803-806
- Zahorsky J (1910) Roseola infantilitis. Pediatrics 22: 60-64
- Zahorsky J (1913) Roseola infantum. JAMA 61: 1446-1450
Recommended articles
Incoming links (6)
Herpesviridae; HHV-6; Roseola infantum; Rose rash of infants; Sixth disease; Three-day fever;Outgoing links (10)
Coxsackie virus infection; Erythema infectiosum; Flu; Herpesviridae; Measles; Mononucleosis infectious; Paracetamol; Rash; Scarlet fever; Shaking mixture;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
