DefinitionThis section has been translated automatically.
Chronic recurrent eosinophilic dermatosis in hematologic neoplasia is a rare (just over 200 patients have been described to date - Cohen PR 2020), multiform, "paraneoplastic" disorder whose common denominator is histo- and blood eosinophilia in underlying leukemic lymphoid neoplasia (Almeida FT et al 2020).
Occurrence/EpidemiologyThis section has been translated automatically.
Figures on incidence are not yet known; m:w=1.3:1.0
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EtiopathogenesisThis section has been translated automatically.
The pathogenesis of the disease has not yet been elucidated. However, it is likely that neoplastic B cells, directly or indirectly (by stimulating a reactive polyclonal T cell response), play an etiologic role. Furthermore, the recruitment of eosinophils to the skin may be secondary to a shift in the immune system toward a T helper 2 response, possibly caused by the neoplastic cells, leading these T cells to produce interleukin-4 (Cohen PR 2020).
Clinical featuresThis section has been translated automatically.
Clinically, itchy erythematous plaques, often arranged in a zoster-like pattern, are present; disseminated nodules and blisters reminiscent of insect bites or occurring after previous insect bites may also be detectable.
Most commonly, these changes are associated with chronic lymphocytic leukemia (CLL) (in a larger compilation of 208 patients, 160 were diagnosed with CLL - Cohen PR 2020). Less commonly, there is an association with mycosis fungoides (Lucas-Truyols S et al 2017).
TherapyThis section has been translated automatically.
Therapeutically, dupilumab is recommended (Jin A et al 2019).
LiteratureThis section has been translated automatically.
- Almeida FT et al (2020) Eosinophilic dermatosis of hematologic malignancy: a case report. Dermatol Online J 26:13030/qt4k8908jb.
Bari O et al. (2017) Eosinophilic dermatosis of hematologic malignancy mimicking varicella zoster infection: report in a woman with chronic lymphocytic leukemia and review of the literature. Dermatol Pract Concept 7:6-15.
- Cohen PR (2020) What's in a name? a new nomenclature has been proposed For eosinophilic dermatosis of hematologic malignancy (EDHM): hematologic-related malignancy-induced eosinophilic dermatosis (He Remained). Dermatol Online J 26: 13030/qt1zd6p6z2.
- Jin A et al. (2019) Eosinophilic dermatosis of hematologic malignancy responding to dupilumab in a patient with chronic lymphocytic leukemia. JAAD Case Rep 5:815-817.
- Lucas-Truyols S et al (2017) Eosinophilic dermatosis of hematologic malignancy. Actas Dermosifiliogr 108:e39-e44.
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