Eosinophilia and skin Grunderkrankung + D72.1

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 28.10.2022

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Dermatoses eosinophils; Eosinophilic dermatoses; Eosinophilic skin diseases; Hypereosinophilic dermatoses; Skin diseases eosinophils

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Skin manifestations characterized by eosinophilic infiltration of the skin (e.g., accompanying insect bites, drug reactions, atopic dermatitits, or other neoplastic or immmunological misreactions) and/or by hematoeosinophilia.

Eosinophilia is the elevation of the normal value of eosinophilic granulocytes in blood (normal value: 2-4% or 50-500/µl) or tissues. Hematoeosinophilia is present when the absolute number of eosinophils of 500/µl is exceeded (> 50% of total leukocytes).

The formerly used term "hypereosinophilia" (> 1500/µl) is no longer in use and is only used nomenclatorically in the so-called hypereosinophilia syndrome.

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  • Primary eosinophilia:
    • clonal eosinophilia
    • idiopathic eosinophilia.
  • Secondary eosinophilia:
    • reactive eosinophilia.
  • Primary eosinophilias include clonal and idiopathic forms. Clonal eosinophilias are predominantly hematologic neoplasms or myelodysplastic and -proliferative disorders.
  • Reactive (or secondary) eosinophilias include all conditions in which a short-term or persistent eosinophilia always occurs in association with a detectable disease (e.g., parasitic disease, malignant tumors, other eosinophilic organ diseases such as eosinophilic esophagitis, gastritis, pneumonia, pancreatitis, myocarditis) or cause (e.g., drugs) of nonclonal origin. Numerous dermatologic diseases are also included here.

The following is a list of diseases that are constantly or inconstantly accompanied by blood eosinophilia:

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Most common cause in Europe is allergies (> 20% of the population); increasingly, drugs are the cause of eosinophilia. Worldwide, parasitoses: depending on the region, up to 80% of the population may be affected.

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Procedure for eosinophilia:
  • Medical history (allergies, atopy, family history, medication, vaccinations, travel history)
  • Physical examination (which organs are involved, skin, heart, lungs, GIT)
  • Laboratory: blood count, ECP, stool tests (parasites), prick, RAST

Notice! A eosinophile count > 1500/ul is rather unusual for allergic diseases. The constellation of haematoeosinophilia and non-specific skin symptoms requires haematological clarification.

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A rearrangement of the genes of the "platelet-derived growth-factor receptor" (PDGFR) alpha and beta can be detected in various clonal hemato-eosinophilia. By inhibition of certain cytoplasmic tyrosinases ( imatinib) influenced by this receptor, primary eosinophilia can be successfully treated.

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  1. Wozel G (2007) Eosinophilic dermatoses. Dermatologist 58: 347-360


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 28.10.2022