HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
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EtiopathogenesisThis section has been translated automatically.
Pathogenetically, the localization at chronic light-exposed, mostly hyperpigmented skin areas indicates chronic actinic damage of the cutaneous connective tissue. The resulting loss of elasticity of the connective tissue leads to horn retention in the follicles at the exposed sites (zygomatic bone), to multiple open, black stained, actinic comedones. The follicles are widened by the horn retention. In addition to open comedones, closed epithelial cysts can also be found in advanced clinical pictures. This results in a mixed picture of actinic elastosis, grouped (non-inflammatory) black comedones and deep-seated epithelial cysts.
ManifestationThis section has been translated automatically.
LocalizationThis section has been translated automatically.
Clinical featuresThis section has been translated automatically.
Thickened, yellowish, but mostly clearly brownish, hyperpigmented, wrinkled (elastotic) skin over the zygomatic arches, in the lateral periorbital and temporal region as well as on the nose (so-called lemon skin) and neck(cutis rhomboidalis nuchae).
Single, but mostly grouped, non-inflamed comedones, with black corneal plugs in strongly dilated follicular openings (open comedones) as well as larger whitish-yellowish follicular cysts filled with crumbly fatty masses (closed comedones). In the zygomatic region mostly distinct hypertrichosis.
Rarely ectopic localisation is possible (so-called actinic comedone plaque on the forearm).
Frequently in combination with cutaneous precanceroses or carcinoma formations. Rarely the clinical picture is an indication of an underlying porphyria cutanea tarda.
HistologyThis section has been translated automatically.
Severe laminar or nodular elastosis of the upper and middle dermis, completely replacing the normal texture of the dermis; enlarged horny follicles with hair segments, atrophy of the follicle wall and sebaceous glands. Frequent melanin deposits in the superficial horny lamellae.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Breit S et al (2003) Favre-Racouchot-like disease after radiation therapy. J Am Acad Dermatol 49: 117-119
- Favre M (1932) Sur une affection kystique des appareils pilo-sébacés localisée à certaines régions de la face. Bull Soc Franc Derm Syph (Lyon) 39: 93-96
- Favre M, Racouchot J (1951) L'élastéidose cutanée nodulaire à kystes et à comédons. Ann Derm Syph 78: 681-702
- Lewis KG et al (2004) Acquired disorders of elastic tissue: part I. Increased elastic tissue and solar elastotic syndromes. J Am Acad Dermatol 51: 1-21
- Lugo A et al (2005) Bullous solar elastosis. At J Dermatopathol 27: 34-35
- Mavilia L et al (2002) Unilateral nodular elastosis with cysts and comedones (Favre-Racouchot syndrome): report of two cases treated with a new combined therapeutic approach. Dermatology 204: 251
- Patterson WM et al (2004) Favre-Racouchot disease. Int J Dermatol 43: 167-169
- Racouchot J (1937) L'élastéidose localisée nodulaire à kystes et à comédons. Thèse de Lyon
- Siragusa M et al (2000) An unusual location of nodular elastosis with cysts and comedones (Favre-Racouchot's disease). Acta Derm Venereol 80: 452
- Stefanidou M et al (2001) Unilateral nodular elastosis with cysts and comedones (Favre-Racouchot syndrome). Dermatology 202: 270-271
Incoming links (18)Atrophy senile of the skin; Colloidalmilium; Dermabrasion; Élastéidose cutanée nodulaire à kystes et à comédons favre-racouchot; Elastoidosis cutanea nodularis; Elastoidosis cutanée nodulaire à kystes et à comédons; Elastosis; Elastosis, nodular with cysts and comedones; Giant comedo; Komedo; ... Show all
Outgoing links (9)Actinic elastosis; Atrophy of the skin (overview); Cutis rhomboidalis nuchae; Isotretinoin; Komedo; Light protection; Porphyria cutanea tarda; Retinoids; Tretinoin;
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