DefinitionThis section has been translated automatically.
Widely used NSAID (non-steroidal anti-inflammatory drug: market share approx. 65%) with pronounced analgesic, antipyretic, antiphlogistic opioid-sparing effect. Also possible as an analgesic enhancing additive to paracetamol or metamizole (balanced analgesia).
PharmacokineticsThis section has been translated automatically.
Very potent antiphlogistic analgesic (10-20 times more potent against COX-2 than against COX-1).
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IndicationThis section has been translated automatically.
Inflammation, painful swelling, rheumatoid arthritis, arthrosis.
Since increased COX 2 levels in carcinoma in situ, type "actinic keratosis" can be detected (also in spinocellular carcinomas), a 3% local therapeutic agent (diclofenac-hyaluronic acid gel) is successfully used for actinic keratoses.
Dosage and method of useThis section has been translated automatically.
Undesirable effectsThis section has been translated automatically.
Systemic therapy: gastrointestinal ulcers, exanthema, photosensitivity.
With local application: redness, itching and rarely allergic contact reactions.
PreparationsThis section has been translated automatically.
- Voltaren®, Duravolten®, Effekton®, Diclofenac-ratiopharm®.
- Solaraze® (local therapeutic agent)
Note(s)This section has been translated automatically.
LiteratureThis section has been translated automatically.
- Jage J (2009) Key questions on the therapy of postoperative pain. Georg Thieme Publishing House, Stuttgart S.16-21
- Merk HF (2007) Topical diclofenac in the treatment of actinic keratoses. Int J Dermatol 46: 8-12
Prof. Dr. med. Peter Altmeyer