Darian sign

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Darian sign; Darier's sign; Sign of Darier

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It was mentioned in scientific publications as early as 1869 by Edward Nettleship and 1878 by Sangster.

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Simple clinical test which, together with the typical skin lesions and histological examination, leads to the diagnosis of cutaneous mastocytosis (e.g. urticaria pigmentosa or mastocytoma). If the lesions are rubbed or scratched, within a few seconds there is a localised, typical, strong redness and possibly urticarial swelling, possibly itching or, rarely, blistering (positive rubbing test). The Darier sign has a high diagnostic value for cutaneous mastocytosis.


Last updated on: 29.10.2020