Colchici semen

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.09.2023

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Synonym(s)

Autumn timeless seeds; semen colchici; Timeless seeds

Definition
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Semen colchici, the official preparations of the seeds of autumn cro cus contains preparations of the dried and crushed seeds. Treatment with autumn crocus seeds can be done only if the preparations are adjusted to an exact amount of colchicine.

ESCOP mon ograph: no editing

HMPC monograph: no editing

Commission E-monograph: positive evaluation for auten gout attack; Familial Mediterranean fever.

Ingredients
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Efficacy determining ingredients are about 20 different colchicine alkaloids with the main alkaloid colchicine. Furthermore fatty oil, proteins, sugar.

Effects
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According to the Commission E: antichemotactic, antiphlogistic, mitosis inhibiting. Popular in rheumatic diseases ; experimental in autoimmunological diseases, local in actinic keratoses.

Field of application/use
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Acute onset of gout, familial Mediterranean fever. Experimentally topical in actinic keratoses; furthermore in autoinflammatory syndromes like PAFA.

Dosage
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In acute attacks of gout 1mg p.o. followed by repetitive doses (at 1-2 hourly intervals) of 0.5mg-1.0mg. A daily dose of 8.0mg must not be exceeded.

Undesirable effects
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Diarrhoea, nausea, vomiting (see package insert of finished products)

Contraindication
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Impaired kidney function, blood work. (e.g. anemia), known gastrointestinal diseases, reduced cardiovascular function, polymorbidity, liver disease, children, adolescents, pregnancy.

Trade names
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Colchicum-Dispert® coated tablet

Note(s)
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Colchicine is toxic. The lethal dose is about 20mg. Both drug and pure colchicine are prescription drugs.

Literature
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  1. Dustin P (1963. New aspects of the pharmacology of antimitotic agents. Pharmacol Rev15: 449-480.
  2. Faghihi G et al (2016) Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study. Adv Med doi: 10.1155/2016/5918393.
  3. Finkelstein Y et al(2010) Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila) 48: 407-414.
  4. Vanoni F et al (2016) PFAPA syndrome: a review on treatment and outcome. Pediatrics Rheumatol Online J 14:38.

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Last updated on: 29.09.2023