Claudine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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The claudins (from lat. claudere - to close) comprise a group of 20-27 kDa large, highly conserved (already detectable in nematodes) transmembrane proteins. They are an important component of the cell connections found in epithelia (see cell contacts below), the so-called tight junctions. So far, 24 different human claudins (claudin-1/ claudin-24) have been detected. Remarkably, the coding genes are not present in a cluster, but are distributed on different chromosomes.

Claudin1 is expressed in various neurogenic tumors and serves as a diagnostic marker.

The isoform 2 of claudin-18, CLDN 18.2, is physiologically expressed in the epithelial cells of the stomach mucosa. Claudin 18.2 is overexpressed in a large number of tumor cells. This is also the case in gastric, pancreatic and esophageal cancer as well as in non-small cell lung cancer (NSCLC) and its metastases. Claudin 18.2 is a target protein for a targeted tumor therapy of various solid tumors (see below Claudiximab).

Literature
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  1. Hayashi T et al (2013) Hybrid schwannoma/perineurioma of the spinal nerve: multifocal occurrence, and recurrence as an intraneural perineurioma. Catholic Int 63:368-373.

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Last updated on: 29.10.2020