DefinitionThis section has been translated automatically.
Pharmacodynamics (Effect)This section has been translated automatically.
Bleomycin induces in experimental systems the increased expression of extracellular matrix proteins, especially alpha(I)collagen, fibronectin and decorin. In addition, bleomycin stimulates cytokines that play a role in dermal fibrosis, such as the "monocyte chemoattractant protein-1" (MCP-1 protein) and one of its receptors (CCR-2).
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Undesirable effectsThis section has been translated automatically.
InteractionsThis section has been translated automatically.
Cisplatin: cumulative nephrotoxicity; G-CSF: increased pulmonary toxicity; methotrexate: increased toxicity; phenytoin: decrease in blood levels; oxygen: prolonged exposure to oxygen (anesthesia) results in increased pulmonary toxicity.
LiteratureThis section has been translated automatically.
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- Yamamoto T, Nishioka K (2002) Animal model of sclerotic skin. V: Increased expression of alpha-smooth muscle actin in fibroblastic cells in bleomycin-induced scleroderma. Clin Immunol 102: 77-83
- Yamamoto T et al (2000) Bleomycin increases steady-state levels of type I collagen, fibronectin and decorin mRNAs in human skin fibroblasts. Arch Dermatol Res 292: 556-561
- Yamamoto T, Nishioka K (2003) Role of monocyte chemoattractant protein-1 and its receptor, CCR-2, in the pathogenesis of bleomycin-induced scleroderma. J Invest Dermatol 121: 510-516