Synonym(s)
Adaptor-Related Protein Complex 1; Adaptor-Related Protein Complex 1 Subunit Sigma-1C 3 4; PSORS15
DefinitionThis section has been translated automatically.
The gene codes for an evolutionary conserved protein which is a component of the adaptor-related protein complex 1 (AP-1) and is involved in the exchange of cellular subcompartments between the Golgi apparatus and endosomes. In AIDS, disturbances in AP-1 function lead to an incorrect recognition of the HIV antigen by cytotoxic T cells. Furthermore, the function of TLR-3(toll-like receptor-3) can be significantly disturbed.
Mutations of the AP1S3 gene have been detected in pustulosa generalisata psoriasis and pustulosis palmaris et plantaris.
Prof. Dr. med. Peter Altmeyer